Genome‐wide association study of body mass index in 23 000 individuals with and without asthma
Identifieur interne : 004A54 ( Main/Exploration ); précédent : 004A53; suivant : 004A55Genome‐wide association study of body mass index in 23 000 individuals with and without asthma
Auteurs : E. Melén [Suède, États-Unis] ; R. Granell [Royaume-Uni] ; M. Kogevinas [Espagne, Grèce] ; D. Strachan [Royaume-Uni] ; J. R. Gonzalez [Espagne] ; M. Wjst [Allemagne] ; D. Jarvis [Royaume-Uni] ; M. Ege [Allemagne] ; C. Braun-Fahrl Nder [Suisse] ; J. Genuneit [Allemagne] ; E. Horak [Autriche] ; E. Bouzigon [France] ; F. Demenais [France] ; F. Kauffmann [France] ; V. Siroux [France] ; S. Michel [Allemagne] ; A. Von Berg [Allemagne] ; A. Heinzmann [Allemagne] ; M. Kabesch [Allemagne] ; N. M. Probst-Hensch [Suisse] ; I. Curjuric [Suisse] ; M. Imboden [Suisse] ; T. Rochat [Suisse] ; J. Henderson [Royaume-Uni] ; J. A. C. Sterne [Royaume-Uni] ; W. L. Mcardle [Royaume-Uni] ; J. Hui [Australie] ; A. L. James [Australie] ; A. William Musk [Australie] ; L. J. Palmer [Canada] ; A. Becker [Canada] ; A. L. Kozyrskyj [Canada] ; M. Chan-Young [Canada] ; J. E. Park [Canada] ; A. Leung [Canada] ; D. Daley [Canada] ; M. B. Freidin [Russie] ; I. A. Deev [Russie] ; L. M. Ogorodova [Russie] ; V. P. Puzyrev [Russie] ; J. C. Celed N [États-Unis] ; J. M. Brehm [États-Unis] ; M. M. Cloutier [États-Unis] ; G. Canino ; E. Acosta-Pérez ; M. Soto-Quiros [Costa Rica] ; L. Avila [Costa Rica] ; A. Bergström [Suède] ; J. Magnusson [Suède] ; C. Söderh Ll [Suède] ; I. Kull [Suède] ; S. Scholtens [Pays-Bas] ; H. Marike Boezen [Pays-Bas] ; G. H. Koppelman [Pays-Bas] ; A. H. Wijga [Pays-Bas] ; I. Marenholz [Allemagne] ; J. Esparza-Gordillo [Allemagne] ; S. Lau [Allemagne] ; Y. Lee [Allemagne] ; M. Standl [Allemagne] ; C. M. T. Tiesler [Allemagne] ; C. Flexeder [Allemagne] ; J. Heinrich [Allemagne] ; R. A. Myers [États-Unis] ; C. Ober [États-Unis] ; D. L. Nicolae [États-Unis] ; M. Farrall [Royaume-Uni] ; A. Kumar [Suisse, Royaume-Uni] ; M. F. Moffatt [Royaume-Uni] ; W. O. C. M. Cookson [Royaume-Uni] ; J. Lasky-Su [États-Unis]Source :
- Clinical & Experimental Allergy [ 0954-7894 ] ; 2013-04.
Descripteurs français
- Wicri :
- topic : Allergie, épidémiologie, Génétique, Santé publique.
English descriptors
- KwdEn :
- Adult studies, Allele, Allergy, Allergy clin immunol, Association analyses, Association studies, Association study, Asthma, Asthma status, Asthmatic, Asthmatic adults, Asthmatic children, Beta values, Biol chem, Blackwell publishing, Body mass index, Capps, Charles gairdner hospital, Child studies, Childhood asthma, Chromosome, Clin, Cohort, College station, Community health sciences, Complex associations, Complex disorders, Continuous trait, Dennd1b, Dennd1b loci, Dennd1b snps, Dennd1b variants, Effect allele, Epidemiology, European descent, Forest plot, Further study, Gabriel studies, Gacrs, Genet, Genetic component, Genetic determinants, Genetic factors, Genetic variants, Genetics, Gwas, Gwas analyses, Gwas data, Gwas results, Healthy individuals, Heterogeneity, Heterogeneous effect, Human genetics, Illumina, Imperial college, Important gene, Independent data sets, Independent replication data sets, Intracranial aneurysm, Inverse variance method, Karolinska institutet, Locus, Lung institute, Manhattan plot, Minor allele, Minor allele frequency, National heart, National institute, Null distribution, Obesity, Original asthma gwas, Other studies, Overall estimate, Pediatric, Pediatric pneumology, Pediatric pulmonology, Plos genet, Polycystic ovary syndrome, Power reasons, Primary biliary cirrhosis, Public health, Puerto rico, Random effects analysis, Random effects model, Regional plot, Replication, Replication data, Replication data sets, Replication studies, Research institute, Respective tables, Sample size, Screening data, Several snps, Silver spring, Snp, Standard deviation, Strong evidence, Study design, Study weight, Tomsk, Total replication data, Total sample size, True associations, Twin studies, Variant, Western australia, Wtccc cohort.
- Teeft :
- Adult studies, Allele, Allergy, Allergy clin immunol, Association analyses, Association studies, Association study, Asthma, Asthma status, Asthmatic, Asthmatic adults, Asthmatic children, Beta values, Biol chem, Blackwell publishing, Body mass index, Capps, Charles gairdner hospital, Child studies, Childhood asthma, Chromosome, Clin, Cohort, College station, Community health sciences, Complex associations, Complex disorders, Continuous trait, Dennd1b, Dennd1b loci, Dennd1b snps, Dennd1b variants, Effect allele, Epidemiology, European descent, Forest plot, Further study, Gabriel studies, Gacrs, Genet, Genetic component, Genetic determinants, Genetic factors, Genetic variants, Genetics, Gwas, Gwas analyses, Gwas data, Gwas results, Healthy individuals, Heterogeneity, Heterogeneous effect, Human genetics, Illumina, Imperial college, Important gene, Independent data sets, Independent replication data sets, Intracranial aneurysm, Inverse variance method, Karolinska institutet, Locus, Lung institute, Manhattan plot, Minor allele, Minor allele frequency, National heart, National institute, Null distribution, Obesity, Original asthma gwas, Other studies, Overall estimate, Pediatric, Pediatric pneumology, Pediatric pulmonology, Plos genet, Polycystic ovary syndrome, Power reasons, Primary biliary cirrhosis, Public health, Puerto rico, Random effects analysis, Random effects model, Regional plot, Replication, Replication data, Replication data sets, Replication studies, Research institute, Respective tables, Sample size, Screening data, Several snps, Silver spring, Snp, Standard deviation, Strong evidence, Study design, Study weight, Tomsk, Total replication data, Total sample size, True associations, Twin studies, Variant, Western australia, Wtccc cohort.
Abstract
Both asthma and obesity are complex disorders that are influenced by environmental and genetic factors. Shared genetic factors between asthma and obesity have been proposed to partly explain epidemiological findings of co‐morbidity between these conditions.
Url:
- https://api.istex.fr/document/DB402DB52E8C99D73CA866B5733514BD116869BE/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608930
DOI: 10.1111/cea.12054
Affiliations:
- Allemagne, Australie, Autriche, Canada, Costa Rica, Espagne, France, Grèce, Pays-Bas, Royaume-Uni, Russie, Suisse, Suède, États-Unis
- Angleterre, Attique (région), Australie-Occidentale, Auvergne-Rhône-Alpes, Bade-Wurtemberg, Basse-Saxe, Bavière, Berlin, Catalogne, District de Fribourg-en-Brisgau, District de Haute-Bavière, District de Tübingen, Grand Londres, Groningue (province), Illinois, Manitoba, Massachusetts, Oxfordshire, Pennsylvanie, Rhône-Alpes, Svealand, Île-de-France
- Athènes, Barcelone, Berlin, Boston, Chicago, Fribourg-en-Brisgau, Grenoble, Groningue, Hanovre, Londres, Munich, Oxford, Paris, Pittsburgh, Stockholm, Ulm, Winnipeg
- Université Louis-et-Maximilien de Munich, Université d'Oxford, Université d'Ulm, Université de Londres, Université du Manitoba
Links toward previous steps (curation, corpus...)
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Le document en format XML
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Melén</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Institute of Environmental Medicine, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, MA, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Suède</country></affiliation></author><author><name sortKey="Granell, R" sort="Granell, R" uniqKey="Granell R" first="R." last="Granell">R. Granell</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Social and Community Medicine, University of Bristol</wicri:regionArea><wicri:noRegion>University of Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Kogevinas, M" sort="Kogevinas, M" uniqKey="Kogevinas M" first="M." last="Kogevinas">M. Kogevinas</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre for Research in Environmental Epidemiology (CREAL), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Municipal Institute of Medical Research (IMIM‐Hospital del Mar), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Grèce</country><wicri:regionArea>National School of Public Health, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Strachan, D" sort="Strachan, D" uniqKey="Strachan D" first="D." last="Strachan">D. Strachan</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Community Health Sciences, St George's, University of London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Gonzalez, J R" sort="Gonzalez, J R" uniqKey="Gonzalez J" first="J. R." last="Gonzalez">J. R. Gonzalez</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre for Research in Environmental Epidemiology (CREAL), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Wjst, M" sort="Wjst, M" uniqKey="Wjst M" first="M." last="Wjst">M. Wjst</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut for Inhalation Biology, Helmholtz Zentrum München, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Jarvis, D" sort="Jarvis, D" uniqKey="Jarvis D" first="D." last="Jarvis">D. Jarvis</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ege, M" sort="Ege, M" uniqKey="Ege M" first="M." last="Ege">M. Ege</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Children's Hospital Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Braun Ahrl Nder, C" sort="Braun Ahrl Nder, C" uniqKey="Braun Ahrl Nder C" first="C." last="Braun-Fahrl Nder">C. Braun-Fahrl Nder</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Tropical and Public Health Institute, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Genuneit, J" sort="Genuneit, J" uniqKey="Genuneit J" first="J." last="Genuneit">J. Genuneit</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Ulm, Institute of Epidemiology and Medical Biometry, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Horak, E" sort="Horak, E" uniqKey="Horak E" first="E." last="Horak">E. Horak</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Pediatrics and Adolescents, Division of Cardiology and Pulmonology, Innsbruck Medical University, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Bouzigon, E" sort="Bouzigon, E" uniqKey="Bouzigon E" first="E." last="Bouzigon">E. Bouzigon</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U946, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Diderot, Paris 7, Institut Universitaire d'Hématologie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Fondation Jean Dausset‐Centre d'Etude du Polymorphisme Humain (CEPH), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Demenais, F" sort="Demenais, F" uniqKey="Demenais F" first="F." last="Demenais">F. Demenais</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U946, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Diderot, Paris 7, Institut Universitaire d'Hématologie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Fondation Jean Dausset‐Centre d'Etude du Polymorphisme Humain (CEPH), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Kauffmann, F" sort="Kauffmann, F" uniqKey="Kauffmann F" first="F." last="Kauffmann">F. Kauffmann</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, CESP Centre for research in Epidemiology and Population Health, Respiratory and Environmental Epidemiology Team, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Univ Paris Sud 11, UMRS 1018, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Siroux, V" sort="Siroux, V" uniqKey="Siroux V" first="V." last="Siroux">V. Siroux</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U823, Centre de Recherche Albert Bonniot, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Univ Joseph Fourier‐ Grenoble 1</wicri:regionArea></affiliation></author><author><name sortKey="Michel, S" sort="Michel, S" uniqKey="Michel S" first="S." last="Michel">S. Michel</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Von Berg, A" sort="Von Berg, A" uniqKey="Von Berg A" first="A." last="Von Berg">A. Von Berg</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Research Institute for the Prevention of Allergic Diseases, Children's Department, Marien‐Hospital, Wesel</wicri:regionArea><wicri:noRegion>Wesel</wicri:noRegion><wicri:noRegion>Wesel</wicri:noRegion></affiliation></author><author><name sortKey="Heinzmann, A" sort="Heinzmann, A" uniqKey="Heinzmann A" first="A." last="Heinzmann">A. Heinzmann</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Children's Hospital, Albert Ludwigs University, Freiburg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Kabesch, M" sort="Kabesch, M" uniqKey="Kabesch M" first="M." last="Kabesch">M. Kabesch</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Probst Ensch, N M" sort="Probst Ensch, N M" uniqKey="Probst Ensch N" first="N. M." last="Probst-Hensch">N. M. Probst-Hensch</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Tropical and Public Health Institute, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Curjuric, I" sort="Curjuric, I" uniqKey="Curjuric I" first="I." last="Curjuric">I. Curjuric</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Tropical and Public Health Institute, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Imboden, M" sort="Imboden, M" uniqKey="Imboden M" first="M." last="Imboden">M. Imboden</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Tropical and Public Health Institute, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Rochat, T" sort="Rochat, T" uniqKey="Rochat T" first="T." last="Rochat">T. Rochat</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Division of Pulmonary Medicine, University Hospitals of Geneva</wicri:regionArea><wicri:noRegion>University Hospitals of Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Henderson, J" sort="Henderson, J" uniqKey="Henderson J" first="J." last="Henderson">J. Henderson</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Social and Community Medicine, University of Bristol</wicri:regionArea><wicri:noRegion>University of Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Sterne, J A C" sort="Sterne, J A C" uniqKey="Sterne J" first="J. A. C." last="Sterne">J. A. C. Sterne</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Social and Community Medicine, University of Bristol</wicri:regionArea><wicri:noRegion>University of Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Mcardle, W L" sort="Mcardle, W L" uniqKey="Mcardle W" first="W. L." last="Mcardle">W. L. Mcardle</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Social and Community Medicine, University of Bristol</wicri:regionArea><wicri:noRegion>University of Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Hui, J" sort="Hui, J" uniqKey="Hui J" first="J." last="Hui">J. Hui</name><affiliation wicri:level="2"><country>Australie</country><placeName><region type="state">Australie-Occidentale</region></placeName><wicri:cityArea>Molecular Genetics, PathWest Laboratory Medicine WA, Nedlands</wicri:cityArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital</wicri:regionArea><wicri:noRegion>Sir Charles Gairdner Hospital</wicri:noRegion></affiliation></author><author><name sortKey="James, A L" sort="James, A L" uniqKey="James A" first="A. L." last="James">A. L. James</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital</wicri:regionArea><wicri:noRegion>Sir Charles Gairdner Hospital</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Pulmonary Physiology/West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital</wicri:regionArea><wicri:noRegion>Sir Charles Gairdner Hospital</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine and Pharmacology</wicri:regionArea></affiliation></author><author><name sortKey="William Musk, A" sort="William Musk, A" uniqKey="William Musk A" first="A." last="William Musk">A. William Musk</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital</wicri:regionArea><wicri:noRegion>Sir Charles Gairdner Hospital</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Respiratory Medicine, Sir Charles Gairdner Hospital</wicri:regionArea><wicri:noRegion>Sir Charles Gairdner Hospital</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Schools of Population Health and Medicine and Pharmacology, University of Western Australia</wicri:regionArea><wicri:noRegion>University of Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Palmer, L J" sort="Palmer, L J" uniqKey="Palmer L" first="L. J." last="Palmer">L. J. Palmer</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Ontario Institute for Cancer Research, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Samuel Lunenfeld Research Institute, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Becker, A" sort="Becker, A" uniqKey="Becker A" first="A." last="Becker">A. Becker</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pediatrics and Child Health, University of Manitoba, Manitoba, Winnipeg</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Kozyrskyj, A L" sort="Kozyrskyj, A L" uniqKey="Kozyrskyj A" first="A. L." last="Kozyrskyj">A. L. Kozyrskyj</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta and School of Public Health, University of Alberta, Edmonton</wicri:regionArea><wicri:noRegion>Edmonton</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Community Health Sciences, Faculty of Medicine, University of Manitoba, Manitoba, Winnipeg</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Chan Oung, M" sort="Chan Oung, M" uniqKey="Chan Oung M" first="M." last="Chan-Young">M. Chan-Young</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Occupational and Environmental Lung Disease Unit, University of British Colombia, BC, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Park, J E" sort="Park, J E" uniqKey="Park J" first="J. E." last="Park">J. E. Park</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>James Hogg iCAPTURE Center, University of British Columbia, BC, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Leung, A" sort="Leung, A" uniqKey="Leung A" first="A." last="Leung">A. Leung</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>James Hogg iCAPTURE Center, University of British Columbia, BC, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Daley, D" sort="Daley, D" uniqKey="Daley D" first="D." last="Daley">D. Daley</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>James Hogg iCAPTURE Center, University of British Columbia, BC, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Freidin, M B" sort="Freidin, M B" uniqKey="Freidin M" first="M. B." last="Freidin">M. B. Freidin</name><affiliation wicri:level="1"><country xml:lang="fr">Russie</country><wicri:regionArea>Research Institute of Medical Genetics of the Siberian Branch of Russian Academy of Medical Sciences, Tomsk</wicri:regionArea><wicri:noRegion>Tomsk</wicri:noRegion></affiliation></author><author><name sortKey="Deev, I A" sort="Deev, I A" uniqKey="Deev I" first="I. A." last="Deev">I. A. Deev</name><affiliation wicri:level="1"><country xml:lang="fr">Russie</country><wicri:regionArea>Siberian State Medical University, Tomsk</wicri:regionArea><wicri:noRegion>Tomsk</wicri:noRegion></affiliation></author><author><name sortKey="Ogorodova, L M" sort="Ogorodova, L M" uniqKey="Ogorodova L" first="L. M." last="Ogorodova">L. M. Ogorodova</name><affiliation wicri:level="1"><country xml:lang="fr">Russie</country><wicri:regionArea>Research Institute of Medical Genetics of the Siberian Branch of Russian Academy of Medical Sciences, Tomsk</wicri:regionArea><wicri:noRegion>Tomsk</wicri:noRegion></affiliation></author><author><name sortKey="Puzyrev, V P" sort="Puzyrev, V P" uniqKey="Puzyrev V" first="V. P." last="Puzyrev">V. P. Puzyrev</name><affiliation wicri:level="1"><country xml:lang="fr">Russie</country><wicri:regionArea>Research Institute of Medical Genetics of the Siberian Branch of Russian Academy of Medical Sciences, Tomsk</wicri:regionArea><wicri:noRegion>Tomsk</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Russie</country><wicri:regionArea>Siberian State Medical University, Tomsk</wicri:regionArea><wicri:noRegion>Tomsk</wicri:noRegion></affiliation></author><author><name sortKey="Celed N, J C" sort="Celed N, J C" uniqKey="Celed N J" first="J. C." last="Celed N">J. C. Celed N</name><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pediatric Pulmonology, Allergy and Immunology, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, PA, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Brehm, J M" sort="Brehm, J M" uniqKey="Brehm J" first="J. M." last="Brehm">J. M. Brehm</name><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pediatric Pulmonology, Allergy and Immunology, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, PA, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Cloutier, M M" sort="Cloutier, M M" uniqKey="Cloutier M" first="M. M." last="Cloutier">M. M. Cloutier</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Connecticut Health Center, CT, Farmington</wicri:regionArea><wicri:noRegion>Farmington</wicri:noRegion></affiliation></author><author><name sortKey="Canino, G" sort="Canino, G" uniqKey="Canino G" first="G." last="Canino">G. Canino</name><affiliation><wicri:noCountry code="subField">PR</wicri:noCountry></affiliation></author><author><name sortKey="Acosta Erez, E" sort="Acosta Erez, E" uniqKey="Acosta Erez E" first="E." last="Acosta-Pérez">E. Acosta-Pérez</name><affiliation><wicri:noCountry code="subField">PR</wicri:noCountry></affiliation></author><author><name sortKey="Soto Uiros, M" sort="Soto Uiros, M" uniqKey="Soto Uiros M" first="M." last="Soto-Quiros">M. Soto-Quiros</name><affiliation wicri:level="1"><country xml:lang="fr">Costa Rica</country><wicri:regionArea>Division of Pediatric Pulmonology, Hospital Nacional de Niños, San José</wicri:regionArea><wicri:noRegion>San José</wicri:noRegion></affiliation></author><author><name sortKey="Avila, L" sort="Avila, L" uniqKey="Avila L" first="L." last="Avila">L. Avila</name><affiliation wicri:level="1"><country xml:lang="fr">Costa Rica</country><wicri:regionArea>Division of Pediatric Pulmonology, Hospital Nacional de Niños, San José</wicri:regionArea><wicri:noRegion>San José</wicri:noRegion></affiliation></author><author><name sortKey="Bergstrom, A" sort="Bergstrom, A" uniqKey="Bergstrom A" first="A." last="Bergström">A. Bergström</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Institute of Environmental Medicine, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Magnusson, J" sort="Magnusson, J" uniqKey="Magnusson J" first="J." last="Magnusson">J. Magnusson</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Institute of Environmental Medicine, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Soderh Ll, C" sort="Soderh Ll, C" uniqKey="Soderh Ll C" first="C." last="Söderh Ll">C. Söderh Ll</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Kull, I" sort="Kull, I" uniqKey="Kull I" first="I." last="Kull">I. Kull</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Institute of Environmental Medicine, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Scholtens, S" sort="Scholtens, S" uniqKey="Scholtens S" first="S." last="Scholtens">S. Scholtens</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Marike Boezen, H" sort="Marike Boezen, H" uniqKey="Marike Boezen H" first="H." last="Marike Boezen">H. Marike Boezen</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Koppelman, G H" sort="Koppelman, G H" uniqKey="Koppelman G" first="G. H." last="Koppelman">G. H. Koppelman</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Wijga, A H" sort="Wijga, A H" uniqKey="Wijga A" first="A. H." last="Wijga">A. H. Wijga</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven</wicri:regionArea><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation></author><author><name sortKey="Marenholz, I" sort="Marenholz, I" uniqKey="Marenholz I" first="I." last="Marenholz">I. Marenholz</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Pediatric Pneumology and Immunology, Charité, BerlinBerlinBerlinBerlin</wicri:regionArea><wicri:noRegion>BerlinBerlinBerlinBerlin</wicri:noRegion><wicri:noRegion>BerlinBerlinBerlinBerlin</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max‐Delbrück‐Centrum (MDC) for Molecular Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Esparza Ordillo, J" sort="Esparza Ordillo, J" uniqKey="Esparza Ordillo J" first="J." last="Esparza-Gordillo">J. Esparza-Gordillo</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Pediatric Pneumology and Immunology, Charité, BerlinBerlinBerlinBerlin</wicri:regionArea><wicri:noRegion>BerlinBerlinBerlinBerlin</wicri:noRegion><wicri:noRegion>BerlinBerlinBerlinBerlin</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max‐Delbrück‐Centrum (MDC) for Molecular Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Lau, S" sort="Lau, S" uniqKey="Lau S" first="S." last="Lau">S. Lau</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Pediatric Pneumology and Immunology, Charité, BerlinBerlinBerlinBerlin</wicri:regionArea><wicri:noRegion>BerlinBerlinBerlinBerlin</wicri:noRegion><wicri:noRegion>BerlinBerlinBerlinBerlin</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Y" sort="Lee, Y" uniqKey="Lee Y" first="Y." last="Lee">Y. Lee</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Pediatric Pneumology and Immunology, Charité, BerlinBerlinBerlinBerlin</wicri:regionArea><wicri:noRegion>BerlinBerlinBerlinBerlin</wicri:noRegion><wicri:noRegion>BerlinBerlinBerlinBerlin</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max‐Delbrück‐Centrum (MDC) for Molecular Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Standl, M" sort="Standl, M" uniqKey="Standl M" first="M." last="Standl">M. Standl</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Tiesler, C M T" sort="Tiesler, C M T" uniqKey="Tiesler C" first="C. M. T." last="Tiesler">C. M. T. Tiesler</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Ludwig‐Maximilians‐University of Munich, Dr. von Hauner Children's Hospital, Division of Metabolic Diseases and Nutritional Medicine, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Flexeder, C" sort="Flexeder, C" uniqKey="Flexeder C" first="C." last="Flexeder">C. Flexeder</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Heinrich, J" sort="Heinrich, J" uniqKey="Heinrich J" first="J." last="Heinrich">J. Heinrich</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Myers, R A" sort="Myers, R A" uniqKey="Myers R" first="R. A." last="Myers">R. A. Myers</name><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Human Genetics, University of Chicago, IL, Chicago</wicri:regionArea><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Ober, C" sort="Ober, C" uniqKey="Ober C" first="C." last="Ober">C. Ober</name><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Human Genetics, University of Chicago, IL, Chicago</wicri:regionArea><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Nicolae, D L" sort="Nicolae, D L" uniqKey="Nicolae D" first="D. L." last="Nicolae">D. L. Nicolae</name><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Human Genetics, Statistics, and Medicine, University of Chicago, IL, Chicago</wicri:regionArea><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Farrall, M" sort="Farrall, M" uniqKey="Farrall M" first="M." last="Farrall">M. Farrall</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Kumar, A" sort="Kumar, A" uniqKey="Kumar A" first="A." last="Kumar">A. Kumar</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Tropical and Public Health Institute, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Moffatt, M F" sort="Moffatt, M F" uniqKey="Moffatt M" first="M. F." last="Moffatt">M. F. Moffatt</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Heart and Lung Institute (NHLI), Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Cookson, W O C M" sort="Cookson, W O C M" uniqKey="Cookson W" first="W. O. C. M." last="Cookson">W. O. C. M. Cookson</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Heart and Lung Institute (NHLI), Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lasky U, J" sort="Lasky U, J" uniqKey="Lasky U J" first="J." last="Lasky-Su">J. Lasky-Su</name><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, MA, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical & Experimental Allergy</title><title level="j" type="alt">CLINICAL AND EXPERIMENTAL ALLERGY</title><idno type="ISSN">0954-7894</idno><idno type="eISSN">1365-2222</idno><imprint><biblScope unit="vol">43</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="463">463</biblScope><biblScope unit="page" to="474">474</biblScope><biblScope unit="page-count">12</biblScope><date type="published" when="2013-04">2013-04</date></imprint><idno type="ISSN">0954-7894</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0954-7894</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult studies</term><term>Allele</term><term>Allergy</term><term>Allergy clin immunol</term><term>Association analyses</term><term>Association studies</term><term>Association study</term><term>Asthma</term><term>Asthma status</term><term>Asthmatic</term><term>Asthmatic adults</term><term>Asthmatic children</term><term>Beta values</term><term>Biol chem</term><term>Blackwell publishing</term><term>Body mass index</term><term>Capps</term><term>Charles gairdner hospital</term><term>Child studies</term><term>Childhood asthma</term><term>Chromosome</term><term>Clin</term><term>Cohort</term><term>College station</term><term>Community health sciences</term><term>Complex associations</term><term>Complex disorders</term><term>Continuous trait</term><term>Dennd1b</term><term>Dennd1b loci</term><term>Dennd1b snps</term><term>Dennd1b variants</term><term>Effect allele</term><term>Epidemiology</term><term>European descent</term><term>Forest plot</term><term>Further study</term><term>Gabriel studies</term><term>Gacrs</term><term>Genet</term><term>Genetic component</term><term>Genetic determinants</term><term>Genetic factors</term><term>Genetic variants</term><term>Genetics</term><term>Gwas</term><term>Gwas analyses</term><term>Gwas data</term><term>Gwas results</term><term>Healthy individuals</term><term>Heterogeneity</term><term>Heterogeneous effect</term><term>Human genetics</term><term>Illumina</term><term>Imperial college</term><term>Important gene</term><term>Independent data sets</term><term>Independent replication data sets</term><term>Intracranial aneurysm</term><term>Inverse variance method</term><term>Karolinska institutet</term><term>Locus</term><term>Lung institute</term><term>Manhattan plot</term><term>Minor allele</term><term>Minor allele frequency</term><term>National heart</term><term>National institute</term><term>Null distribution</term><term>Obesity</term><term>Original asthma gwas</term><term>Other studies</term><term>Overall estimate</term><term>Pediatric</term><term>Pediatric pneumology</term><term>Pediatric pulmonology</term><term>Plos genet</term><term>Polycystic ovary syndrome</term><term>Power reasons</term><term>Primary biliary cirrhosis</term><term>Public health</term><term>Puerto rico</term><term>Random effects analysis</term><term>Random effects model</term><term>Regional plot</term><term>Replication</term><term>Replication data</term><term>Replication data sets</term><term>Replication studies</term><term>Research institute</term><term>Respective tables</term><term>Sample size</term><term>Screening data</term><term>Several snps</term><term>Silver spring</term><term>Snp</term><term>Standard deviation</term><term>Strong evidence</term><term>Study design</term><term>Study weight</term><term>Tomsk</term><term>Total replication data</term><term>Total sample size</term><term>True associations</term><term>Twin studies</term><term>Variant</term><term>Western australia</term><term>Wtccc cohort</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Adult studies</term><term>Allele</term><term>Allergy</term><term>Allergy clin immunol</term><term>Association analyses</term><term>Association studies</term><term>Association study</term><term>Asthma</term><term>Asthma status</term><term>Asthmatic</term><term>Asthmatic adults</term><term>Asthmatic children</term><term>Beta values</term><term>Biol chem</term><term>Blackwell publishing</term><term>Body mass index</term><term>Capps</term><term>Charles gairdner hospital</term><term>Child studies</term><term>Childhood asthma</term><term>Chromosome</term><term>Clin</term><term>Cohort</term><term>College station</term><term>Community health sciences</term><term>Complex associations</term><term>Complex disorders</term><term>Continuous trait</term><term>Dennd1b</term><term>Dennd1b loci</term><term>Dennd1b snps</term><term>Dennd1b variants</term><term>Effect allele</term><term>Epidemiology</term><term>European descent</term><term>Forest plot</term><term>Further study</term><term>Gabriel studies</term><term>Gacrs</term><term>Genet</term><term>Genetic component</term><term>Genetic determinants</term><term>Genetic factors</term><term>Genetic variants</term><term>Genetics</term><term>Gwas</term><term>Gwas analyses</term><term>Gwas data</term><term>Gwas results</term><term>Healthy individuals</term><term>Heterogeneity</term><term>Heterogeneous effect</term><term>Human genetics</term><term>Illumina</term><term>Imperial college</term><term>Important gene</term><term>Independent data sets</term><term>Independent replication data sets</term><term>Intracranial aneurysm</term><term>Inverse variance method</term><term>Karolinska institutet</term><term>Locus</term><term>Lung institute</term><term>Manhattan plot</term><term>Minor allele</term><term>Minor allele frequency</term><term>National heart</term><term>National institute</term><term>Null distribution</term><term>Obesity</term><term>Original asthma gwas</term><term>Other studies</term><term>Overall estimate</term><term>Pediatric</term><term>Pediatric pneumology</term><term>Pediatric pulmonology</term><term>Plos genet</term><term>Polycystic ovary syndrome</term><term>Power reasons</term><term>Primary biliary cirrhosis</term><term>Public health</term><term>Puerto rico</term><term>Random effects analysis</term><term>Random effects model</term><term>Regional plot</term><term>Replication</term><term>Replication data</term><term>Replication data sets</term><term>Replication studies</term><term>Research institute</term><term>Respective tables</term><term>Sample size</term><term>Screening data</term><term>Several snps</term><term>Silver spring</term><term>Snp</term><term>Standard deviation</term><term>Strong evidence</term><term>Study design</term><term>Study weight</term><term>Tomsk</term><term>Total replication data</term><term>Total sample size</term><term>True associations</term><term>Twin studies</term><term>Variant</term><term>Western australia</term><term>Wtccc cohort</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Allergie</term><term>épidémiologie</term><term>Génétique</term><term>Santé publique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Both asthma and obesity are complex disorders that are influenced by environmental and genetic factors. Shared genetic factors between asthma and obesity have been proposed to partly explain epidemiological findings of co‐morbidity between these conditions.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Canada</li><li>Costa Rica</li><li>Espagne</li><li>France</li><li>Grèce</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Russie</li><li>Suisse</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Attique (région)</li><li>Australie-Occidentale</li><li>Auvergne-Rhône-Alpes</li><li>Bade-Wurtemberg</li><li>Basse-Saxe</li><li>Bavière</li><li>Berlin</li><li>Catalogne</li><li>District de Fribourg-en-Brisgau</li><li>District de Haute-Bavière</li><li>District de Tübingen</li><li>Grand Londres</li><li>Groningue (province)</li><li>Illinois</li><li>Manitoba</li><li>Massachusetts</li><li>Oxfordshire</li><li>Pennsylvanie</li><li>Rhône-Alpes</li><li>Svealand</li><li>Île-de-France</li></region><settlement><li>Athènes</li><li>Barcelone</li><li>Berlin</li><li>Boston</li><li>Chicago</li><li>Fribourg-en-Brisgau</li><li>Grenoble</li><li>Groningue</li><li>Hanovre</li><li>Londres</li><li>Munich</li><li>Oxford</li><li>Paris</li><li>Pittsburgh</li><li>Stockholm</li><li>Ulm</li><li>Winnipeg</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li><li>Université d'Oxford</li><li>Université d'Ulm</li><li>Université de Londres</li><li>Université du Manitoba</li></orgName></list><tree><noCountry><name sortKey="Acosta Erez, E" sort="Acosta Erez, E" uniqKey="Acosta Erez E" first="E." last="Acosta-Pérez">E. Acosta-Pérez</name><name sortKey="Canino, G" sort="Canino, G" uniqKey="Canino G" first="G." last="Canino">G. Canino</name></noCountry><country name="Suède"><region name="Svealand"><name sortKey="Melen, E" sort="Melen, E" uniqKey="Melen E" first="E." last="Melén">E. Melén</name></region><name sortKey="Bergstrom, A" sort="Bergstrom, A" uniqKey="Bergstrom A" first="A." last="Bergström">A. Bergström</name><name sortKey="Kull, I" sort="Kull, I" uniqKey="Kull I" first="I." last="Kull">I. Kull</name><name sortKey="Magnusson, J" sort="Magnusson, J" uniqKey="Magnusson J" first="J." last="Magnusson">J. Magnusson</name><name sortKey="Melen, E" sort="Melen, E" uniqKey="Melen E" first="E." last="Melén">E. Melén</name><name sortKey="Melen, E" sort="Melen, E" uniqKey="Melen E" first="E." last="Melén">E. Melén</name><name sortKey="Soderh Ll, C" sort="Soderh Ll, C" uniqKey="Soderh Ll C" first="C." last="Söderh Ll">C. Söderh Ll</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Melen, E" sort="Melen, E" uniqKey="Melen E" first="E." last="Melén">E. Melén</name></region><name sortKey="Brehm, J M" sort="Brehm, J M" uniqKey="Brehm J" first="J. M." last="Brehm">J. M. Brehm</name><name sortKey="Celed N, J C" sort="Celed N, J C" uniqKey="Celed N J" first="J. C." last="Celed N">J. C. Celed N</name><name sortKey="Cloutier, M M" sort="Cloutier, M M" uniqKey="Cloutier M" first="M. M." last="Cloutier">M. M. Cloutier</name><name sortKey="Lasky U, J" sort="Lasky U, J" uniqKey="Lasky U J" first="J." last="Lasky-Su">J. Lasky-Su</name><name sortKey="Myers, R A" sort="Myers, R A" uniqKey="Myers R" first="R. A." last="Myers">R. A. Myers</name><name sortKey="Nicolae, D L" sort="Nicolae, D L" uniqKey="Nicolae D" first="D. L." last="Nicolae">D. L. Nicolae</name><name sortKey="Ober, C" sort="Ober, C" uniqKey="Ober C" first="C." last="Ober">C. Ober</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Granell, R" sort="Granell, R" uniqKey="Granell R" first="R." last="Granell">R. Granell</name></noRegion><name sortKey="Cookson, W O C M" sort="Cookson, W O C M" uniqKey="Cookson W" first="W. O. C. M." last="Cookson">W. O. C. M. Cookson</name><name sortKey="Farrall, M" sort="Farrall, M" uniqKey="Farrall M" first="M." last="Farrall">M. Farrall</name><name sortKey="Henderson, J" sort="Henderson, J" uniqKey="Henderson J" first="J." last="Henderson">J. Henderson</name><name sortKey="Jarvis, D" sort="Jarvis, D" uniqKey="Jarvis D" first="D." last="Jarvis">D. Jarvis</name><name sortKey="Kumar, A" sort="Kumar, A" uniqKey="Kumar A" first="A." last="Kumar">A. Kumar</name><name sortKey="Kumar, A" sort="Kumar, A" uniqKey="Kumar A" first="A." last="Kumar">A. Kumar</name><name sortKey="Mcardle, W L" sort="Mcardle, W L" uniqKey="Mcardle W" first="W. L." last="Mcardle">W. L. Mcardle</name><name sortKey="Moffatt, M F" sort="Moffatt, M F" uniqKey="Moffatt M" first="M. F." last="Moffatt">M. F. Moffatt</name><name sortKey="Sterne, J A C" sort="Sterne, J A C" uniqKey="Sterne J" first="J. A. C." last="Sterne">J. A. C. Sterne</name><name sortKey="Strachan, D" sort="Strachan, D" uniqKey="Strachan D" first="D." last="Strachan">D. Strachan</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Kogevinas, M" sort="Kogevinas, M" uniqKey="Kogevinas M" first="M." last="Kogevinas">M. Kogevinas</name></region><name sortKey="Gonzalez, J R" sort="Gonzalez, J R" uniqKey="Gonzalez J" first="J. R." last="Gonzalez">J. R. Gonzalez</name><name sortKey="Gonzalez, J R" sort="Gonzalez, J R" uniqKey="Gonzalez J" first="J. R." last="Gonzalez">J. R. Gonzalez</name><name sortKey="Kogevinas, M" sort="Kogevinas, M" uniqKey="Kogevinas M" first="M." last="Kogevinas">M. 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